| Divisione | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| # | Divisione Centrale | PG | V | VS | SS | P | R | P | Forma |
| 1. | Chicago Fire | 22 | 15 | 1 | 2 | 4 | 44:24 | 48 | |
| 2. | Columbus Crew | 20 | 12 | 1 | 0 | 7 | 40:27 | 39 | |
| 3. | FC Dallas | 21 | 8 | 2 | 1 | 10 | 43:42 | 30 | |
| 4. | Mutiny | 25 | 4 | 0 | 1 | 20 | 28:64 | 12 | |
| # | Divisione Est | PG | V | VS | SS | P | R | P | Forma |
| 1. | Miami | 21 | 16 | 0 | 0 | 5 | 50:29 | 48 | |
| 2. | New York Red Bulls | 23 | 13 | 0 | 0 | 10 | 36:33 | 39 | |
| 3. | DC United | 24 | 8 | 0 | 1 | 15 | 39:47 | 24 | |
| 4. | New England Revolution | 21 | 6 | 1 | 0 | 14 | 28:45 | 21 | |
| # | Divisione Ovest | PG | V | VS | SS | P | R | P | Forma |
| 1. | Los Angeles Galaxy | 21 | 11 | 3 | 0 | 7 | 44:28 | 42 | |
| 2. | Houston Dynamo | 20 | 13 | 0 | 0 | 7 | 42:24 | 39 | |
| 3. | Sporting Kansas City | 24 | 11 | 0 | 2 | 11 | 31:51 | 33 | |
| 4. | Colorado Rapids | 18 | 5 | 0 | 1 | 12 | 24:35 | 15 | |